Article Topics

The field of bioelectronic medicine combines molecular medicine, bioengineering, and neuroscience to discover and develop nerve stimulating and sensing technologies to regulate biological processes and treat disease.

Work submitted to the journal will cover topics in these disciplines but may also expand to topics in the fields of disease biology, bioinformatics, bioengineering, materials science, nanotechnology, neurosurgery, and device development. Ethical, legal and financial issues related to bioelectronic medicine and device development are welcomed. Significant negative results will be considered. 

The following are examples (not limitations) of topics which may be considered by the journal: basic science, preclinical science, clinical studies, transcranial modulation, telemetry, modeling, model-based control, neural decoding, algorithms, and related tools (i.e. electrodes).

Gastrointestinal Electrical Neuromodulation for Functional Gastrointestinal Diseases, Obesity and Diabetes

Jieyun Yin and Jiande DZ Chen
Along the gut, there are rhythmic myoelectrical activities called slow waves that regulate gastrointestinal motility. Impairment in gastrointestinal slow waves and motility causes various disorders such as gastroesophageal reflux disease, gastroparesis and constipation. Gastrointestinal electrical stimulation has been introduced for the treatment of various motility diseases along the gut. Alternations in gastrointestinal motility are associated with the releases of gastrointestinal hormones, whereas changes in gastrointestinal hormones are believed to be associated with obesity and diabetes. Electrophysiology and motility of the gut are briefly reviewed. Common methods of gastrointestinal electrical stimulation are introduced. Promising or possible applications of these neuromodulation methods for treating gastroesophageal reflux disease, gastroparesis and constipation are discussed. Therapeutic potentials of electrical stimulation of the gut for the treatment of obesity and diabetes are also presented and discussed.
Bioelectronic Medicine 2015
Page Range
Date Published
January 28, 2015
Article PDF
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Yin, Chen, gastrointestinal disease, neurostimulation, gastrointestinal electrical stimulation, gastroesophageal reflux disease, obesity, diabetes
Article Type
Invited Review Article