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Article Topics

The field of bioelectronic medicine combines molecular medicine, bioengineering, and neuroscience to discover and develop nerve stimulating and sensing technologies to regulate biological processes and treat disease.

Work submitted to the journal will cover topics in these disciplines but may also expand to topics in the fields of disease biology, bioinformatics, bioengineering, materials science, nanotechnology, neurosurgery, and device development. Ethical, legal and financial issues related to bioelectronic medicine and device development are welcomed. Significant negative results will be considered. 

The following are examples (not limitations) of topics which may be considered by the journal: basic science, preclinical science, clinical studies, transcranial modulation, telemetry, modeling, model-based control, neural decoding, algorithms, and related tools (i.e. electrodes).

Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes

Authors
William M Hanes, Peder S Olofsson, Sébastien Talbot, Tea Tsaava, Mahendar Ochani, Gavin H Imperato, Yaakov A Levine, Jesse Roth, Maud A Pascal, Simmie L Foster, Ping Wang, Clifford Woolf, Sangeeta S Chavan, and Kevin J Tracey
Abstract
When pathogens and toxins breech the epithelial barrier, antigens are transported by the lymphatic system to lymph nodes. In previously immunized animals, antigens become trapped in the draining lymph nodes, but the underlying mechanism that controls antigen restriction is poorly understood. Here we describe the role of neurons in sensing and restricting antigen flow in lymph nodes. The antigen keyhole-limpet hemocyanin (KLH) injected into the mouse hind paw flows from the popliteal lymph node to the sciatic lymph node, continuing through the upper lymphatics to reach the systemic circulation. Re-exposure to KLH in previously immunized mice leads to decreased flow from the popliteal to the sciatic lymph node as compared with naïve mice. Administering bupivacaine into the lymph node region restores antigen flow in immunized animals. In contrast, neural activation using magnetic stimulation significantly decreases antigen trafficking in naïve animals as compared with sham controls. Ablating NaV1.8 sensory neurons significantly reduces antigen restriction in immunized mice. Genetic deletion of FcγRI/FcεRI also reverses the antigen restriction. Colocalization of PGP9.5-expressing neurons, FcγRI receptors and labeled antigen occurs at the antigen challenge site. Together, these studies reveal that neuronal circuits modulate antigen trafficking through a pathway that requires NaV1.8 and FcγR.
Volume
Bioelectronic Medicine 2016
Page Range
18-29
DOI
10.15424/bioelectronmed.2016.00001
Date Published
December 20, 2016
Article PDF
New fileNew description4291 KB
Keywords
Hanes, Olofsson, Talbot, Tsaava, Ochani, Imperato, Levine, Roth, Pascal, Foster, Wang, Woolf, Chavan,Tracey, antigens, neuronal circuits, lymph nodes, neurons, bioelectronic medicine
Article Type
Research Article