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Article Topics
The field of bioelectronic medicine combines molecular medicine, bioengineering, and neuroscience to discover and develop nerve stimulating and sensing technologies to regulate biological processes and treat disease.
Work submitted to the journal will cover topics in these disciplines but may also expand to topics in the fields of disease biology, bioinformatics, bioengineering, materials science, nanotechnology, neurosurgery, and device development. Ethical, legal and financial issues related to bioelectronic medicine and device development are welcomed. Significant negative results will be considered.
The following are examples (not limitations) of topics which may be considered by the journal: basic science, preclinical science, clinical studies, transcranial modulation, telemetry, modeling, model-based control, neural decoding, algorithms, and related tools (i.e. electrodes).
Work submitted to the journal will cover topics in these disciplines but may also expand to topics in the fields of disease biology, bioinformatics, bioengineering, materials science, nanotechnology, neurosurgery, and device development. Ethical, legal and financial issues related to bioelectronic medicine and device development are welcomed. Significant negative results will be considered.
The following are examples (not limitations) of topics which may be considered by the journal: basic science, preclinical science, clinical studies, transcranial modulation, telemetry, modeling, model-based control, neural decoding, algorithms, and related tools (i.e. electrodes).
Microchannel Electrode Stimulation of Deep Peroneal Nerve Fascicles Induced Mean Arterial Depressor Response in Hypertensive Rats
Authors
Young-tae Kim, Aswini Kanneganti, Caleb Nothnagle, Ryan Landrith, Masaki Mizuno, Muthu B J Wijesundara, Scott Smith, and Mario I Romero-Ortega
Abstract
Hypertension (HTN) affects over 1 billion people in the world, and while most are treated effectively with pharmacological regimens, 10–30% of them do not show a beneficial response. Electrical stimulation of the renal sympathetic, vagus and carotid sinus nerves has shown depressor effects and has been proposed as an alternative treatment for resistant hypertension (R-HTN). However, these nerves are heterogeneous in afferent/efferent composition, and their stimulation often results in unwanted side effects.
We evaluated the possibility of eliciting a depressor response from stimulation of single fascicle of the somatic deep peroneal nerve (fDPN). A microchannel electrode array (μCEA) was used to stimulate the fDPN at low frequency, which induced a significant (p ≤ 0.03) transient reduction in mean arterial pressure (MAP) with no significant effects on heart rate. The depressor response was prolonged for several hours by extending the fDPN stimulation to 5 min, which induced significant reduction (17–25%) in MAP for up to 4 h. Immunofluorescence evaluation of the axonal marker, myelin, and active macrophages in the fDPN revealed no indication of nerve damage or overt inflammation in response to the procedure. This study provides evidence supporting the use of μCEA interfacing of small somatic nerve fascicles associated with cardiovascular relevant acupoints to induce significant reductions in MAP and opens the possibility of neuromodulation of small fascicles as an alternative strategy to treat R-HTN with minimal side effects. Further, the μCEA multielectrode array offers an effective tool for neuromodulation of small nerve fascicles, enabling a number of possible future medical bioelectronic applications.
Volume
Bioelectronic Medicine 2015
Page Range
55-62
DOI
10.15424/bioelectronmed.2015.00001
Date Published
August 28, 2015
Article PDF
Keywords
Hypertension,HTN,Electrical Stimulation,Deep Peroneal Nerve Fascicles,Kim,Kanneganti,Nothnagle,Landrith,Mizuno,Wijesundara,Smith,Romero-Ortega
Article Type
Research Article
