Kevin J Tracey, MD
The Feinstein Institute for Medical Research
Manhasset, NY, USA Email
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All Articles
Title:
Neurostimulation of the Cholinergic Antiinflammatory Pathway in Rheumatoid Arthritis and Inflammatory Bowel Disease
Authors:
Yaakov A Levine, Frieda Koopman, Michael Faltys, Ralph Zitnik, and Paul-Peter Tak
Abstract:
Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) cause significant morbidity and mortality. Despite significant therapeutic advances, the medical need for patients with these disorders remains high. An ...
Volume:
Bioelectronic Medicine 2014
Page Range:
34-43
DOI:
10.15424/bioelectronmed.2014.00008
Date Published:
December 2, 2014
Article PDF:
Neurostimulation of the Cholinergic Antiinflammatory Pathway in Rheumatoid Arthritis and Inflammatory Bowel Disease New description 3139 KB
Date Created: 10/28/2015 01:40 PM
Title:
A Stimulating Concept: Bioelectronic Medicine in Inflammatory Disease
Authors:
Peder S Olofsson
Abstract:
Recent discoveries in neuroscience and immunology have revealed that stimulation of specific neural circuits can ameliorate certain experimental inflammatory diseases. Accumulating evidence on a prototypical reflex circuit ...
Volume:
Bioelectronic Medicine 2014
Page Range:
30-33
DOI:
10.15424/bioelectronmed.2014.00007
Date Published:
December 2, 2014
Article PDF:
A Stimulating Concept: Bioelectronic Medicine in Inflammatory Disease New description 188 KB
Date Created: 10/28/2015 01:41 PM
Title:
The Neural Tourniquet
Authors:
Jason R Fritz and Jared M Huston
Abstract:
Bioelectronic medicine aims to understand and harness the beneficial effects of the nervous system and neural circuits to diagnose, treat and prevent disease. For example, targeted electrical stimulation devices can ...
Volume:
Bioelectronic Medicine 2014
Page Range:
25-29
DOI:
10.15424/bioelectronmed.2014.00006
Date Published:
December 2, 2014
Article PDF:
The Neural Tourniquet New description 190 KB
Date Created: 10/28/2015 01:41 PM
Title:
Bioelectronics as a Possible Therapeutic Modality Targeting Sphincteric Dysfunction in Gastrointestinal Disorders
Authors:
Larry Miller and Anil Vegesna
Abstract:
Sphincters in the gastrointestinal tract control the movement of luminal contents in the forward direction and prevent their movement in the backward direction. Defective sphincters are responsible for many of the disorders in ...
Volume:
Bioelectronic Medicine 2014
Page Range:
19-24
DOI:
10.15424/bioelectronmed.2014.00005
Date Published:
December 2, 2014
Article PDF:
Bioelectronics as a Possible Therapeutic Modality Targeting Sphincteric Dysfunction in Gastrointestinal Disorders New description 2287 KB
Date Created: 10/28/2015 01:42 PM
Title:
Graph Theory–Guided Transcranial Magnetic Stimulation in Neurodegenerative Disorders
Authors:
Ji Hyun Ko, Yoon Young Choi, and David Eidelberg
Abstract:
The emergence of brain imaging techniques has shed light on the underlying mechanisms of brain diseases. Abnormalities found in the diseased brain have often been targeted by transcranial magnetic stimulation (TMS), which can ...
Volume:
Bioelectronic Medicine 2014
Page Range:
15-18
DOI:
10.15424/bioelectronmed.2014.00004
Date Published:
December 2, 2014
Article PDF:
Bioelectronics as a Possible Therapeutic Modality Targeting Sphincteric Dysfunction in Gastrointestinal Disorders New description 2287 KB
Date Created: 10/28/2015 01:42 PM
Title:
Bioelectronic Medicine and the Dawn of Robotic Training to Improve Motor Outcome in Chronic Stroke
Authors:
Bruce T Volpe
Abstract:
Engineers and clinicians have cooperated to produce and test new classes of bioelectronics that have altered motor impairment that occurs after stroke. The rationale that increased intensity of training alters outcome derives ...
Volume:
Bioelectronic Medicine 2014
Page Range:
9-14
DOI:
10.15424/bioelectronmed.2014.00002
Date Published:
December 2, 2014
Article PDF:
Bioelectronic Medicine and the Dawn of Robotic Training to Improve Motor Outcome in Chronic Stroke New description 4055 KB
Date Created: 10/28/2015 01:43 PM
Title:
Monitoring the Injured Brain
Authors:
Chunyan Li and Raj K Narayan
Abstract:
Traumatic brain injury is a serious public health problem in the United States, accounting for nearly 1.7 million injuries and 52,000 deaths annually. The initial brain injury is made worse by secondary events which include, but are ...
Volume:
Bioelectronic Medicine 2014
Page Range:
4-8
DOI:
10.15424/bioelectronmed.2014.00010
Date Published:
December 2, 2014
Article PDF:
Monitoring the Injured Brain New description 1053 KB
Title:
Gastrointestinal Electrical Neuromodulation for Functional Gastrointestinal Diseases, Obesity and Diabetes
Authors:
Jieyun Yin and Jiande DZ Chen
Abstract:
Along the gut, there are rhythmic myoelectrical activities called slow waves that regulate gastrointestinal motility. Impairment in gastrointestinal slow waves and motility causes various disorders such as gastroesophageal ...
Volume:
Bioelectronic Medicine 2015
Page Range:
13-19
DOI:
10.15424/bioelectronmed.2015.00002
Date Published:
January 28, 2015
Article PDF:
New file New description 201 KB
Date Created: 11/30/2015 11:42 AM
Title:
Neural Decoding and Applications in Bioelectronic Medicine
Authors:
Chad Bouton
Abstract:
Neural decoding is a field involving the use of signal processing and machine learning methods to decode brain activity for various
applications including assistive technology for people living with paralysis and diagnosing ...
Volume:
Bioelectronic Medicine 2015
Page Range:
20-24
DOI:
10.15424/bioelectronmed.2014.00012
Date Published:
January 28, 2015
Article PDF:
14_012_Bouton.pdf New description 1296 KB
Date Created: 11/30/2015 11:42 AM
Title:
Impact of Bioelectronic Medicine on the Neural Regulation of Pelvic Visceral Function
Authors:
William C de Groat and Changfeng Tai
Abstract:
Neuromodulation elicited by electrical stimulation of peripheral or spinal nerves is a U.S. Food and Drug Administered (FDA)-approved therapy for treating disorders of the pelvic viscera, including urinary urgency, ...
Volume:
Bioelectronic Medicine 2015
Page Range:
25-36
DOI:
10.15424/bioelectronmed.2015.00003
Date Published:
January 22, 2015
Article PDF:
New file New description 9308 KB
Date Created: 11/30/2015 11:43 AM
Title:
Single-Pulse and Unidirectional Electrical Activation of the Cervical Vagus Nerve Reduces Tumor Necrosis Factor in Endotoxemia
Authors:
Peder S Olofsson, Yaakov A Levine, April Caravaca, Sangeeta S Chavan, Valentin A Pavlov, Michael Faltys, and Kevin J Tracey
Abstract:
The inflammatory reflex is a neural circuit defined by action potentials transmitted in the vagus nerve that regulate cytokine production in the spleen. Detailed mechanistic studies implicate the vagus nerve, the splenic nerve, a ...
Volume:
Bioelectronic Medicine 2015
Page Range:
37-42
DOI:
10.15424/bioelectronmed.2015.00006
Date Published:
May 13, 2015
Article PDF:
June 11, 2015 New description 1551 KB
Date Created: 11/30/2015 11:45 AM
Title:
Chronic Electrical Nerve Stimulation as a Therapeutic Intervention for Peripheral Nerve Repair
Authors:
Miyuki Sakuma, Ivan R Minev, Sandra Gribi, Bhagat Singh, Clifford J Woolf, and Stéphanie P Lacour
Abstract:
When a peripheral nerve is injured after either trauma or a neurodegenerative disease, motor function and sensory perception are impaired. Repair strategies aim both at reconstructing the damaged nerve and in promoting ...
Volume:
Bioelectronic Medicine 2015
Page Range:
43-48
DOI:
10.15424/bioelectronmed.2015.00005
Date Published:
July 28, 2015
Article PDF:
New file New description 197 KB
Date Created: 11/30/2015 11:45 AM
Title:
Imagining the Future of Medicine
Authors:
Christopher J Czura
Abstract:
Christopher J. Czura, PhD, is Vice President of the Feinstein Institute for Medical Research, Executive Publisher of the Feinstein Institute
Press’s international, peer-reviewed journals, Molecular Medicine and ...
Volume:
Bioelectronic Medicine 2015
Page Range:
49-50
DOI:
10.15424/bioelectronmed.2015.00004
Date Published:
August 17, 2015
Article PDF:
New file New description 168 KB
Date Created: 11/30/2015 11:46 AM
Title:
Alan Lightman’s Response to “Imagining the Future of Medicine” Commentary
Authors:
Alan Lightman
Abstract:
Alan Lightman, is a novelist, essayist, physicist and educator, who from an early age, was entranced by both science and the arts. Lightman received his AB degree in physics from Princeton University in 1970, Phi Beta Kappa and magna ...
Volume:
Bioelectronic Medicine 2015
Page Range:
51-52
DOI:
10.15424/bioelectronmed.2015.00007
Date Published:
August 17, 2015
Article PDF:
New file New description 166 KB
Date Created: 11/30/2015 11:46 AM
Title:
Melissa Masters’s Response to “Imagining the Future of Medicine” Commentary
Authors:
Melissa Masters
Abstract:
Ms. Masters is Director of Electrical, Software and Systems Engineering at Battelle and heads Battelle’s DeviceSecure Services. Ms. Masters has more than 15 years of experience in product development as a project manager, systems ...
Volume:
Bioelectronic Medicine 2015
Page Range:
53-54
DOI:
10.15424/bioelectronmed.2015.00009
Date Published:
August 17, 2015
Article PDF:
New file New description 165 KB
Date Created: 11/30/2015 11:48 AM
Title:
Microchannel Electrode Stimulation of Deep Peroneal Nerve Fascicles Induced Mean Arterial Depressor Response in Hypertensive Rats
Authors:
Young-tae Kim, Aswini Kanneganti, Caleb Nothnagle, Ryan Landrith, Masaki Mizuno, Muthu B J Wijesundara, Scott Smith, and Mario I Romero-Ortega
Abstract:
Hypertension (HTN) affects over 1 billion people in the world, and while most are treated effectively with pharmacological regimens, 10–30% of them do not show a beneficial response. Electrical stimulation of the renal ...
Volume:
Bioelectronic Medicine 2015
Page Range:
55-62
DOI:
10.15424/bioelectronmed.2015.00001
Date Published:
August 28, 2015
Article PDF:
New file New description 3980 KB
Date Created: 11/30/2015 11:48 AM
Title:
Time Stability and Coherence Analysis of Multiunit, Single-Unit and Local Field Potential Neuronal Signals in Chronically Implanted Brain Electrodes
Authors:
Gaurav Sharma, Nicholas Annetta, David Friedenberg, Tony Blanco, Daphne Vasconcelos, Ammar Shaikhouni, Ali R Rezai, and Chad Bouton
Abstract:
Introducing neural sensing and decoding to open-loop neurostimulation technologies has the potential to significantly improve the diagnosis and treatment of a wide variety of diseases treated through bioelectronic medicine. ...
Volume:
Bioelectronic Medicine 2015
Page Range:
63 - 71
DOI:
10.15424/bioelectronmed.2015.00010
Date Published:
September 9, 2015
Article PDF:
15_010_sharma.pdf New description 3173 KB
Date Created: 11/30/2015 11:49 AM
Title:
Cytokine-specific Neurograms in the Sensory Vagus Nerve
Authors:
Benjamin E Steinberg, Harold A Silverman, Sergio Robbiati, Manoj K Gunasekaran, Téa Tsaava, Emily Battinelli, Andrew Stiegler, Chad E Bouton, Sangeeta S Chavan, Kevin J Tracey, and Patricio T Huerta
Abstract:
The axons of the sensory, or afferent, vagus nerve transmit action potentials to the central nervous system in response to changes in the body’s metabolic and physiological status. Recent advances in identifying neural circuits ...
Volume:
Bioelectronic Medicine 2016
Page Range:
7-17
DOI:
10.15424/bioelectronmed.2016.00007
Date Published:
December 21, 2016
Article PDF:
New file New description 4720 KB
Date Created: 01/17/2017 01:25 PM
Title:
Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes
Authors:
William M Hanes, Peder S Olofsson, Sébastien Talbot, Tea Tsaava, Mahendar Ochani, Gavin H Imperato, Yaakov A Levine, Jesse Roth, Maud A Pascal, Simmie L Foster, Ping Wang, Clifford Woolf, Sangeeta S Chavan, and Kevin J Tracey
Abstract:
When pathogens and toxins breech the epithelial barrier, antigens are transported by the lymphatic system to lymph nodes. In previously immunized animals, antigens become trapped in the draining lymph nodes, but the underlying ...
Volume:
Bioelectronic Medicine 2016
Page Range:
18-29
DOI:
10.15424/bioelectronmed.2016.00001
Date Published:
December 20, 2016
Article PDF:
Title:
Vagus Nerve Stimulation for Treatment of Inflammation:Systematic Review of Animal Models and Clinical Studies
Authors:
Harwood Kwan, Luca Garzoni, Hai Lun Liu, Mingju Cao, Andre Desrochers, Gilles Fecteau,
Patrick Burns, and Martin G Frasch
Abstract:
Vagus nerve stimulation (VNS) has been used since 1997 for treatment of drug-resistant epilepsy. More recently, an off-label use of VNS has been explored in animal models and clinical trials for treatment of a number of conditions ...
Volume:
Bioelectronic Medicine 2016
Page Range:
1-6
DOI:
10.15424/bioelectronmed.2016.00005
Date Published:
September, 14 2016
Article PDF: